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特色領域研究中心
特色領域研究中心
中心主任

中心主任介紹

 

姓名 要點  

余承佳 教授

 

連絡電話要點 

55509; 55538

Email 要點

ccyu@csmu.edu.tw

現職 要點

中山醫學大學口腔醫學院口腔科學研究所教授

  

學歷 要點

學校 科系所
國立陽明大學        牙醫學院口腔生物研究所博士(2005-2009)       

經歷 要點

工作單位

中山醫學大學口腔醫學院口腔科學研究所副教授(2013-2016)    

中山醫學大學口腔醫學院口腔科學研究所助理教授(2010-2013)      

國立陽明大學牙醫學院口腔生物研究所博士後研究(2009-2010)      

                                     

 

           研究方向要點  ►癌幹原性►口腔癌及口腔黏膜下纖維化症致病機制►非編碼RNA


 

研究計畫 要點

校外研究計畫

研究名稱

執行期限

補助
單位

探討口腔癌化中LINC00478低表達促使癌幹性增進及淋巴轉移的分子機制及臨床研究

2016/08/01-2019/07/31

科技部

跨領域發展口腔癌、大腸直腸癌及胰臟癌早期診斷暨疾病進展之新型生物標誌與預防及治療策略 2018/01/01-2021/12/31

衛生署

檜木醇透過調控微核醣核酸miR-513a-5p標靶癌幹細胞及上皮-間質相互轉換特性作為口腔癌化學輔助性療法之研究 2013/08/01-2016/07/31

科技部

微核糖核酸200家族成員於口腔癌癌症幹細胞之角色探討及微核糖核酸200家族成員於口腔癌臨床病理意義之研究 2011/08/01-2014/07/31

科技部

基因在口腔癌腫瘤化對於幹細胞特性維護及惡化進展之功能性研究 2011/01/01-2011/10/31

科技部

長鏈非編碼RNA作為口腔癌前病變及口腔癌新穎診治標的之轉譯研究

2017/08/01-2018/07/31

科技部

探討營養素減緩癌症化學或放射線治療之不良副作用的功效及機轉

2016/08/01-2018/07/31

科技部

口腔黏膜下纖維化症與口腔癌新穎生物標誌開發及有效治療之轉譯研究

2014/08/01-2017/07/31

科技部

口腔癌前病變及口腔癌之預防、治療及致病機轉之探討--口腔癌前病變及口腔癌之預防、治療及致病機轉之探討

2011/08/01-2014/07/31

科技部

以基因體規模的總體基因體學和代謝體學以及免疫學和生物資訊學分析,來搜尋口腔癌早期檢測和診斷的生物標誌

2014/01/01-2017/12/31

衛生署

 

 

論文發表

代表著作(*通訊作者)

1). Chiou SH#, Yu CC#, Huang CY, Lin SC, Liu CJ, Tsai TH, Chou SH, Chien CS, Ku HH, Lo JF* (2008). Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High Grade Oral Squamous Cell Carcinoma. Clin Cancer Res 14:4085-95. (#Equal Contribution) 被引用557次.

2). Wu MJ, Jan CI, Tsai YG, Yu YH, Huang CY, Lin SC, Liu CJ, Chen YS, Lo JF*, Yu CC* (2010). Targeting Head and Neck Cancer Initiating Cells through Glucose Regulated Protein78 signaling. Mol Cancer 9:283. (Highly Accessed) 被引用86次.

3). Lo WL#, Yu CC#, Chiou GY, Chen YW, Huang PI, Chien CS, Tseng LM, Chu PY, Lu KH, Chang KW, Kao SY, Chiou SH* (2011). MicroRNA-200c Attenuates Tumor Growth and Metastasis of Presumptive Head and Neck Squamous Cell Carcinoma Stem Cells. J Pathol 223: 482-95. (#Equal Contribution) 被引用137次.

4). Jan CI#, Yu CC#, Hung MC, Harn HJ, N S, Lee HS, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF* (2011). Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. J Pathol 225: 424-37. (# Equal Contribution; Cover Story) 被引用34次

5). Yu CC*, Chen YW, Chiou GY, Tsai LL, Huang PI, Chang CY, Tseng LM, Yen SH, Chou MY, Chu PY, Lo WL* (2011). MicroRNA Let-7a Represses Chemo-resistance and Tumorigenicity in Head and Neck Cancer via Stem-Like Properties Ablation. Oral Oncol 47: 202-10 (Cover Story) 被引用101次

6). Chen YS, Wu MJ, Huang CY, Lin SC, Chung TH, Yu CC*, Lo JF* (2011). CD133/Src Axis Mediates Tumor Initiating Property and Epithelial-Mesenchymal Transition of Head and Neck Cancer. PLoS One 6: e28053: 1-12. 被引用84次

7). Tsai LL, Yu CC*, Chang YC, Yu CH, Chou MY* (2011). Markedly Increased Oct4 and Nanog Expression Correlates with Cisplatin Resistance in Oral Squmous Cell Carcinoma. J Oral Pathol Med 40: 621-8. 被引用123次

8). Chang CJ, Hsu CC, Chang CH, Tsai LL, Chang YC, Lu SW, Yu CH, Huang HS, Wang JJ, Tsai CH, Chou MY, Yu CC*, Hu FW* (2011). Let-7d Functions as Novel Regulator of Epithelial-Mesenchymal Transition and Chemo-resistant Property in Oral Cancer. Oncol Rep 26: 1003-10. 被引用121次

9). Hu FW, Tsai LL, Yu CH, Chen PN, Chou MY, Yu CC* (2012). Impairment of Tumor Initiating Stem-Like Property and Reversal of Mesenchymal Transdifferentiation in Head and Neck Cancer by Resveratrol Treatment. Mol Nutr Food Res 56:1247-58. 被引用66次

10). Yu CC*, Tsai LL, Wang ML, Yu CH, Lo WL, Chang YC, Chiou GY, Chou MY, Chiou SH* (2013). miR145 targets the SOX9/ADAM17 axis to inhibit tumor initiating cells and IL-6-mediated paracrine effects in head and neck cancer. Cancer Res 73:1-16. 被引用90次

11). Yu CC, Chang YC*(2013). Enhancement of Cancer Stem-like and Epithelial-Mesenchymal Transdifferentiation Property in Oral Epithelial Cells Stimulated with Long-Term Nicotine Exposure: Reversal by Inhibition of Snail. Toxicol Appl Pharmacol 266: 459-469. 被引用35次

12). Yu CC, Tsai CH, Hsu HI, Chang YC* (2013). Elevation of S100A4 Expression in Buccal Mucosal Fibroblasts by Arecoline: Involvement in the Pathogenesis of Oral Submucous Fibrosis. PLoS One 8:e55122. 被引用26次

13). Yu CH, Yu CC* (2014). Photodynamic Therapy with 5-aminolevulinic acid (ALA) Impairs Tumor Initiating and Chemo-resistance Property in Head and Neck Cancer-derived Cancer Stem Cells. PLoS One 9:e87129. 被引用20次

14). Tsai LL, Hu FW, Lee SS. Yu CH, Yu CC*, Chang YC* (2014). Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through regulation of the epithelial-mesenchymal transition. PLoS One 9:e87207. 被引用44次

15). Huang CE, Hu FW, Yu CH, Tsai LL, Lee TH, Chou MY*, Yu CC* (2014). Concurrent expression of Oct4 and Nanog maintains mesenchymal stem-like property of human dental pulp. Int J Mol Sci. 15:18623-39. 被引用24次

16). Chang YC, Jan CI, Peng CY, Lai YC, Hu FW*, Yu CC* (2015). Activation of MicroRNA-494-targeting Bmi1 and ADAM10 by Silibinin Ablates Cancer Stemness and Predicts favourable Prognostic Value in Head and Neck Squamous Cell Carcinomas. Oncotarget 6:24002-16. 被引用26次

17). Chou MY, Hu FW, Yu CH, Yu CC* (2015). SOX2 expression involvement in the oncogenicity and radiochemoresistance of oral cancer stem cells. Oral Oncol 51:31-39. 被引用28次

18). Hu FW, Lee SS, Yang LC, Tsai CH, Chou MY*, Yu CC* (2015). Knockdown of S100A4 impairs arecoline-induced invasiveness of oral squamous cell carcinomas. Oral Oncol 51:690-697.

19). Ho CM, Hu FW, Lee SS, Shieh TM, Yu CH, Lin SS*, Yu CC* (2015). ZEB1 as an indicator of tumor recurrence for areca quid chewing-associated oral squamous cell carcinomas. J Oral Pathol Med. 44:693-8.

20). Lin WT, Shieh TM, Yang LC, Wang TY, Chou MY*, Yu CC*. (2015). Elevated Lin28B expression is correlated with lymph node metastasis in oral squamous cell carcinomas. J Oral Pathol Med. 44:823-30.

21). Yu CC, Hu FW, Yu CH, Chou MY* (2016). Targeting CD133 in the Enhancement of Chemosensitivity in Oral Squamous Cell Carcinomas-derived Side Population Cancer Stem Cells. Head Neck. 38:E231-E238. 被引用17次

22). Yu CC, Yu CH, Chang YC (2016). Aberrant SSEA4 up-regulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis. Sci Rep 6:37004.

23). Yu CC, Chen PN, Peng CY, Yu CH*, Chou MY* (2016). Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasis Oncotarget 7:20180-92.

24). Lee YH, Yang LC, Hu FW, Peng CY, Yu CH*, Yu CC* (2016). Elevation of Twist expression by arecoline contributes the pathogenesis of oral submucous fibrosis. J Formos Med Assoc 115:311-317.(SCI, *Corresponding Author)

25). Liu CM, Peng CY, Liao YW, Lu MY, Tsai ML, Yeh JC, Yu CH* Yu CC* (2017). Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction. J Formos Med Assoc 116:41-48. (SCI, Cited Times:6)

26). Peng CY, Liao YW, Lu MY, Yu CH, Yu CC*, Chou MY* (2017). Down-regulation of miR-1 enhances tumorigenicity and invasiveness in oral squamous cell carcinomas. J Formos Med Assoc 116:782-789.

27). Lee PH, Hsieh PL, Liao YW, Yu CC* (2018). Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and pro-inflammatory cytokines in human fibrotic buccal mucosal fibroblasts. Environ Toxicol 33:32-40.

28). Lee PH, Chu PM, Hsieh PL, Yang HW, Liao YW, Yu CC* (2018). Glabridin inhibits the activation of myofibroblasts in human fibrotic buccal mucosal fibroblasts through TGF-β/Smad signaling. Environ Toxicol 33:248-255.

29). Yang HW, Lu MY, Chiu YW, Liao YW, Huang YF, Chueh PJ, Hsieh PL, Yu CC*(2018). Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail. Environ Toxicol [Epub ahead of print].

30). Yu CC, Liao YW, Yu CH, Chang YC (2018). STRO-1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis. J Oral Pathol Med [Epub ahead of print].

31). Lin CY, Liao YW, Hsieh PL, Lu MY, Peng CY, Chu PM, Yang HW, Huang YF, Yu CC*, Yu CH*(2018). LncRNA GAS5-AS1 inhibits myofibroblasts activities in oral submucous fibrosis. J Formos Med Assoc [Epub ahead of print].