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醫研所楊順發教授

 

團隊教師

 

姓名 要點  

楊順發 副教授

連絡電話 要點

34253

Email 要點

ysf@csmu.edu.tw

現職 要點

中山醫學大學醫研所副教授

  

學歷 要點

學校 科系所 畢業年度
中山醫學大學 生化暨生物科技研究所(博士) 2005/06
中山醫學大學 生化暨生物科技研究所(碩士)  2001/06
中山醫學大學 醫事技術學系(學士)  1999/06

經歷 要點

工作單位 職稱 期間
中山醫學大學醫學研究所 副教授 2009/02 ~ 今
中山醫學大學貴重儀器中心 主任 2010/08 ~ 至今
中山醫學大學附設醫院臨床研究中心 主任 2009/11 ~ 至今

 

研究方向 要點

1. 口腔黏膜下纖維化及口腔癌致病因子及其機制的探討
2. 癌症轉移相關因子其基因多型性與不同癌症的相關性探討
3. 類黃酮與中草藥抑制口腔癌細胞轉移及侵襲的機制探討
   

研究成果 要點

研究計畫

年度

研究名稱

擔任
工作

補助
金額

補助
單位

97

碳酸酐異構酶IX, XII 在口腔黏膜下纖維化及口腔癌的表現

主持人

3,810,000

國科會

98

基質細胞衍生因子(SDF-1)及其受體(CXCR4)在口腔黏膜下纖維化及口腔癌的表現及其機制探討

主持人

3,585,000

國科會

100

Lipocalin-2及其MMP-9複合體在口腔黏膜下纖維化及口腔癌的表現及其機制探討

主持人

918,000

國科會

 

論文發表

年度

著作

期刊

屬性

期刊最佳

百分比

2008

Lee SS, Yang SF, Ho YC, Tsai CH, Chang YC*. The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Oncology 2008; 44: 180-186.

SCI

IF: 2.871 ; Ranking: 6/77: 7.79%

2008

2008 Yang SF, Yang WE, Kuo WH, Chang HR, Chu SC, Hsieh YS*. Antimetastatic potentials of flavones on oral cancer cell via an inhibition of matrix-degrading proteases. Archive of Oral Biology 2008; 53: 287-294.

SCI

IF: 1.463 ; Ranking: 32/77: 41.56%

2008

2008 Huang FM, Yang SF, Chang YC*. Up-regulation of gelatinases and tissue type plasminogen activator by root canal sealers in human osteoblastic cells. Journal of Endodontics 2008; 34: 291-294.

SCI

IF: 3.291 ; Ranking: 3/77: 3.90%

2008

2008 Yang SF, Tsai CH, Chang YC*. The upregulation of heat shock protein 47 expression in human buccal fibroblasts stimulated with arecoline. Journal of Oral Pathology Medicine 2008; 37: 206-210.

SCI

IF: 2.075 ; Ranking: 20/77: 25.97%

2008

2008 Yang SF, Yang WE, Chang HR, Chu SC, Hsieh YS*. Luteolin induces apoptosis in oral squamous cancer cells. Journal of Dental Research 2008; 87: 401-406.

SCI

 IF: 3.773 ; Ranking: 2/77: 2.60%

2008

2008 Lee SS, Yang SF, Tsai CH, Chou MC, Chou MY, Chang YC*. Upregulation of Heme Oxygenase-1 Expression in Areca-quid-chewing-associated Oral Squamous Cell Carcinoma. Journal of the Formosan Medical Association 2008; 107: 355-363.

SCI

IF: 1.125 ; Ranking: 76/153: 49.67%

2009

 Huang FM, Lee SS, Yang SF, Chang YC*. Up-regulation of receptor activator nuclear factor-Kappa B ligand expression by root canal sealers in human osteoblastic cells. Journal of Endodontics 2009; 35: 363-366.

SCI

IF: 3.291 ; Ranking: 3/77: 3.90%

2009

2009 Tsai LL, Yang SF, Tsai CH, Chou MY, Chang YC*. Concomitant upregulation of matrix metalloproteinase-2 in lesions and circulating plasma of oral lichen planus. Journal of Dental Sciences 2009; 4: 7-12.

SCI

IF: 0.286 ; Ranking: 73/77: 94.81%

2009 

2009 Tsai CH, Yang SF, Lee SS, Chang YC*. Augmented heme oxygenase-1 expression in areca quid chewing-associated oral submucous fibrosis. Oral Disease 2009; 15: 281-286.

SCI

IF: 2.145 ; Ranking: 16/77: 20.78%

2009

2009 Huang FM, Tsai CH, Yang SF, Chang YC*. The upregulation of oncostatin M in inflamed human dental pulps. International Endodontic Journal 2009; 42: 627-631.

SCI

IF: 2.383 ; Ranking: 11/77: 14.29%

2009

2009 Tsai CH, Yang SF, Huang FM, Chang YC*. The upregulation of cystatin c in human gingival fibroblasts stimulated with cyclosporine A. Journal of Periodontal Research 2009; 44: 459-464.

SCI

IF: 2.128 ; Ranking: 17/77: 22.08%

2009

Teng YH, Liu TH, Tseng HC, Chung TT, Yeh CM, Li YC, Ou YH, Lin LY, Tsai HT*, Yang SF*. The contribution of genetic polymorphisms of stromal cell- derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathological development of oral cancer. Head & Neck 2009; 31:1282-1288.

SCI

IF: 2.182 ; Ranking: 5/41: 12.20 %

2009

2009 Ho YC, Yang SF, Huang FM, Chang YC*. Up-regulation of osteolytic mediators in human osteosarcoma cells stimulated with nicotine. Journal of Periodontal Research 2009; 44: 760-766.

SCI

IF: 2.128 ; Ranking: 17/77: 22.08%

2009

2009 Chen MK, Chiou HL, Su SC, Chung TT, Tseng HC, Tsai HT*, Yang SF*. The association between Hypoxia Inducible Factor-1 alpha gene polymorphisms and increased susceptibility to oral cancer. Oral Oncology 2009; 45: e222-226.

SCI

IF: 2.871 ; Ranking: 6/77: 7.79%

2010

 Yang SF, Chen MK, Hsieh YS, Yang JS, Zavras AI, Hsieh YH, Su SC, Kao TY, Chen PN, Chu SC*. Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases. Food and Chemical Toxicology 2010; 48: 1502-1508.

SCI

IF: 2.602 ; Ranking: 16/128: 12.50%

2010

2010 Huang FM, Yang SF, Chang YC*. Effects of root canal sealers on alkaline phosphatase in human osteoblastic cells. Journal of Endodontics 2010; 36: 1230-1233.

SCI

IF: 3.291 ; Ranking: 3/77: 3.90%

2010

2010 Chen MK, Tsai HT, Chung TT, Su SC, Kao TY, Tseng HC, Liu TH, Chiou HL*, Yang SF* Glutathione S-transferase pi and alpha gene variants increase susceptibility and tumor size development of oral cancer. Head & Neck 2010; 32: 1079-1087.

SCI

IF: 2.182 ; Ranking: 5/41: 12.20 %

2010

2010 Yang SF, Chen MK, Hsieh YS, Chung TT, Hsieh YH, Lin CW, Su JL, Tsai MH, Tang CH*. Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells. Journal of Biological Chemistry 2010; 285: 29808-29816.

SCI

IF: 5.328 ; Ranking: 50/286: 17.48%

2010

2010 Lee SS, Tsai CH, Yang SF, Ho YC, Chang YC*.  Hypoxia inducible factor-1 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Diseases 2010; 16: 696-701.

SCI

IF: 2.145 ; Ranking: 16/77: 20.78%

2010

2010 Huang FM, Yang SF, Zhao JH, Chang YC*. Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells. Journal of Endodontics 2010; 36: 1628-1632.

SCI

IF: 3.291 ; Ranking: 3/77: 3.90%

2010

2010 Weng CJ, Chien MH, Lin CW, Chung TT, Zavras AI, Tsai CM, Chen MK*, Yang SF*. Effect of CC chemokine ligand 5 and CC chemokine receptor 5 genes polymorphisms on the risk and clinicopathological development of oral cancer. Oral Oncology 2010; 46: 767-772.

SCI

IF: 2.871 ; Ranking: 6/77: 7.79%

2011

 Weng CJ, Lin CW, Chung TT, Tsai CM, Chen MK*, Yang SF*. Impact of uPA system gene polymorphisms on the susceptibility of environmental factors to carcinogenesis and the development of clinicopathology of oral cancer. Annals of Surgical Oncology 2011; 18: 805-812.

SCI

IF: 4.182 ; Ranking: 8/188: 4.26%

2011

2011 Chen MK, Yeh KT, Lin CW, Chung TT, Yang SF*. Zavras AI, Yoon AJ, Chen MK, Lin CW, Yang SF*. Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma. Annals of Surgical Oncology 2011; 18: 1478-1483.

SCI

IF: 4.182 ; Ranking: 8/188: 4.26%

2011

2011 Chen MK, Yeh KT, Lin CW, Chung TT, Yang SF*. CCR2-64I gene polymorphism increase susceptibility to oral cancer. Oral Oncology 2011; 47: 577-582.

SCI

IF: 2.871 ; Ranking: 6/77: 7.79%

2011

2011 Chung TT, Pan MS, Kuo CL, Wong RH, Lin CW, Chen MK, Yang SF* Impact of RECK gene polymorphisms and environmental factors on oral cancer susceptibility and clinicopathologic characteristics in Taiwan. Carcinogenesis 2011; 32: 1063-1068.

SCI

IF: 5.402 ; Ranking: 27/185: 14.59%

2011

2011 Chien MH, Chou LS, Chung TT, Lin CH, Chou MY, Weng MS, Yang SF, Chen MK*. Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of oral cancer. Head & Neck 2011; in press.

SCI

IF: 2.182 ; Ranking: 5/41: 12.20 %

2011

2011 Yoon AJ, Zavras AI, Chen MK, Lin CW, Yang SF*. Association between Gly1619ARG polymorphism of IGF2R domain 11 (rs629849) and advanced stage of oral cancer. Medical Oncology 2011; in press.

SCI

IF: 2.210 ; Ranking: 110/185: 59.46%

2011

2011 Chien MH, Hsin CH, Chou LS, Chung TT, Lin CH, Weng MS, Chou MY, Chen MK*, Yang SF*. Interleukin (IL)-23 receptor polymorphism is a risk factor for oral cancer susceptibility Head & Neck 2011; in press.

SCI

IF: 2.182 ; Ranking: 5/41: 12.20 %

2011 

2011 Chien MH, Lee TS, Kao C, Yang SF, Lee WS*. Terbinafine inhibits oral squamous cell carcinoma growth through anti-cancer cell proliferation and anti-angiogenesis. Molecular carcinogenesis 2011; in press.

SCI

IF: 3.265 ; Ranking: 63/185: 34.05%

2011

2011 Weng CJ, Chen MK, Lin CW, Chung TT, Yang SF* Single nucleotide polymorphisms and haplotypes of MMP-14 are associated to the risk and pathological development of oral cancer. Annals of Surgical Oncology 2011; in press. 

SCI

IF: 4.182 ; Ranking: 8/188: 4.26%

2011

2011 Liu CM, Yeh CJ, Yu CC, Chou MY, Lin CH, Wei LH, Lin CW, Yang SF*, Chien MH*. Impact of Interleukin-8 gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan. Oral Diseases 2011; in press.

SCI

IF: 2.145 ; Ranking: 16/77: 20.78%

2011

2011 Chien MH, Ying TH, Hsieh YH, Lin CH, Shih CH, Wei LH, Yang SF*. Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis. Oral Oncology 2011; in press.

SCI

IF: 2.871 ; Ranking: 6/77: 7.79%

 

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