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姓名 要點  

楊肇基 教授


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學歷 要點

學校 科系所
美國西奈山醫學院 生物醫學博士

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工作單位 職稱





研究方向 要點

分子生物學 細胞生物學

研究成果 要點



Program Name



Functional and Biological studies of a novel, stress-regulated protein kinase, SLK


探討ZAK基因造成心肌肥大的機制 The mechanisms of ZAK on the induction of cardiac hypertrophy


TGF-b 透過ZAK誘導心肌肥大的研究 Study of TGF-b induces hypertrophic growth in Cardiac Cells through ZAK


探討ZAK結合蛋白在ZAK引起心肌肥大時的功能 Functional study of ZAK associated proteins (ZAPs) induces cardiac hypertrophy


研究ZAK促進心肌肥大的機制及利用新穎方法調節ZAK功能 Mechanistic studies on ZAK induced cardiac hypertrophy and employ novel methods to regulate ZAK activities






1).Su, Y. F., Lin, C. C., Huang, T. H. Chou, M. Y., Jaw-Ji Yang, J. J., Shie, M. Y.,(2014), Osteogenesis and angiogenesis properties of dental pulp cell on novel injectable tricalcium phosphate cement by silica doped. Materials Science and Engineering C. 42, 672-680.

2).Su, Y. F, Chi-Yen Liang, C. Y., Huang, C. Y., Peng, C. Y., Chen, C. C., Lin, M. C., Lin, R. K., Lin, W. W., Chou, M. Y., Liao, P. H. and Yang, J. J.,(2014), A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK. Journal of Biomedical Science. 21, 67-.

3).Tsung-Yuan Yang, Janet I. Chou, Kwo-Chang Ueng1, Ming-Yung Chou, Jaw-Ji Yang, Shoei-Yn Lin-Shiau,Ming-E Hu, Jen-Kun Lin,(2014), Weight Reduction Effect of Puerh Tea in Male Patients with Metabolic Syndrome. Phytotherapy Research. 28, 1096-1101.

4).Zeng, Z. M, Chuang, S. M., Chang, T. M., Hong, C. H., Chou, J. C., Yang, J. J., Chueh, P. J. ,(2012), Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells. Experimental Cell Research. 318, 1759-1766.

5).Kuo, C. Y., Lin, Y. C., Yang, J. J., and Yang, V. C.,(2011), Interaction abolishment between mutant caveolin-1(Δ62-100) and ABCA1 reduces HDL-mediated cellular cholesterol efflux. Biochemical and Biophysical Research Communications. 414, 337-343.

6).Yang J. J. , Lee, Y. J., Hung, H. H., Tseng, W. P., Tu, C. C., Lee, H., Wu, W. J.,(2010), ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner. Cancer Science. 101, 1374-1381.

7).Cheng, M. H., Cheng, H. T., Lin, S. S., Young, S. C., Pai, C. J., Liao, P. H., Chen, S. C., Chou, M. Y., Yang, J. J., Yang, C. C. ,(2009), Apoptotic Death Mode of Mitomycin C-Treated HeLa Cells and Cellular Localization of Mitomycin C-induced P-Glycoprotein. Drug and Chemical Toxicology. 32, 158-168.

8).Cheng, Y. C., Kuo, W. W., Wu, H. C., Lai, T. Y., Wu, C. H., Hwang, J. M., Wang, W. H., Tsai, F. J., Yang, J. J. *, Huang, C. Y.*, Chu, C. H.*,(2009), ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells.. Mol. Cell. Biochem.. 325, 69-77.

9).Huang, C. Y., Yang, L. C, Liu, K. Y., Chang, I. C., Liao, P. H., Chou, J. I., Chou, M. Y., Lin, W. W., Yang, J. J. ,(2009), ZAK negatively regulates RhoGDIbeta-induced Rac1-mediated hypertrophic growth and cell migratio. J. Biomedical Science. 16, 56-

10).Huang, C. Y., Yang, L. C., Liu, K. Y., Liao, P. H., Chou, J. I. Y., Chou, M. Y., Lin, W. W., Yang, J. J.,(2009), RhoGDI-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK. J. Biomedical Science. J. Biomedical Science.. 16, 11-.

11).Liu, S. C., Yang, J. J., Shao, K. N., Chueh, P. J. ,(2008), RNA interference targeting tNOX attenuates cell migration via a mechanism that involves membrane association of Rac. Biochemical and Biophysical Research Communications. 365, 672-677.

12).Kao, S. C., Chen, C. Y., Wang, S. L., Yang, J. J., Hung, W. C., Chen, Y. C., Lai, N. S., Liu, H. T., Huang, H. L., Chen, H. C., Lin, T. H., Huang, H.B. ,(2008), Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit. Biochemical and Biophysical Research Communications. 354, 594-598.

13).Tsai, C. W., Chen, H. W., Yang, J. J., Sheen, L. Y., Lii, C. K. ,(2007), Diallyl disulfide and diallyl trisulfide up-regulate the expression of the pi class of glutathione S-transferase via an AP-1-dependent pathway. J Agric Food Chem.. 55, 1019-1026.

14).Li, C.C., Lii, C. K., Liu, K. L., Yang, J. J., Chen, H. W. ,(2007), DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. Toxicology and Applied Pharmacology. 225, 329-336.

15).Chen, L. M., Kuo, W. W., Yang, J. J., Wang, S. G., Yeh, Y. L., Tsai, F. J., Ho, Y. J., Chang, M. H., Huang, C. Y., Lee, S. D. ,(2006), Eccentric Cardiac Hypertrophy was Induced by Long-term Intermittent Hypoxia. Experimental Physiology. 92.2, 409-416.

16).Li, C. C., Lii, C. K., Liu, K. L., Yang, J. J., Chen, H. W,(2006), n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. J Nutr Biochem.. 17, 707-715

17).Tsai, C. W., Chen, H, W., Yang, J. J., Liu, K. L., Lii, C. K. ,(2005), Sulfur amino acids restriction induces the class of glutathione S-transferase expression in primary rat hepatocytes. Journal of Nutrition. 135, 1034-1039.

18).Tsai, C. W., Yang, J. J., Chen, H. W., Sheen, L. Y., Lii, C. K. ,(2005), Garlic Organosulfur Compounds Up-Regulate the Expression of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes. Journal of Nutrition.. 135, 2560-2565.

19).Chang, C. H., Chen, T. H., Hsu, R. C., Chou, P. H., Yang, J. J., and Hwang, G. Y. ,(2005), The prevalence of HPV-18 and variants of E6 gene isolated from cervical cancer patients in Taiwan. Journal of Clinical Virology. 32, 33-37.

20).Li, C. C., Shen, H. L. Lii, C. K. Liu, K. L. Yang, J. J., and Chen, H. W. ,(2005), Prostaglandin E2 down-regulation of cytochrome P-450 2B1 expression induced by phenobarbital is through EP2 receptor in rat hepatocytes. Biochemical and Biophysical Research Communications. 327, 424-430.

21).Yang,Jaw-Ji,(2004), ZAKnre-programs the Expression of Atrial Natriuretic Factor and Induces Hypertrophic Growth in H9c2 Cardiomyoblast Cells. Biochemical and Biophysical Research Communications. 324, 973-980.

22).Yang,Jaw-Ji,(2004), Transforming Growth Factor- (TGF-Induces the Expression of ANF and Hypertrophic Growth in Cultured Cardiomyoblast Cells through ZAK. Biochemical and Biophysical Research Communications. 324, 424-431.

23).Yang,Jaw-Ji,(2004), MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J of Oral Pathology and Medicine. 33, 37-45.

24).Chen, H. W., Tsai, C. W., Yang, J. J., Liu, C. T., Kuoy, W. W., Lii, C. K. ,(2003), The combined effects of garlic oil and fish oil on the hepatic antioxidant and drug-metabolizing enzymes of rats. British J. Nutrition. 89, 189-200.

25).Yang,Jaw-Ji,(2003), A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Biochem. Biophys. Res. Commun.. 301, 71-77.

26).Yang,Jaw-Ji,(2002), Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest. Biochem. Biophys. Res. Commun.. 297, 105-110.

27).Chen, H. W., Yang, J. J., Wu, J. J., Tsai, C. W., Sheen, L. Y., Ou, C. C., and Lii, C. K. ,(2001), Dietary fat and garlic oil respectively regulate hepatic cytochrome P450 2B1 and the placental form of GSH S-Transferase expression. J. Nutrition. 131, 1438-1443.

28).Tsai, C. F., Lii, C. K., Yang, J. J., Liu, K., Lin, W. L., and Chen, H. W. ,(2001), Prostaglandin E2 is involved in the increase of Cytochrome P-450 2B1 expression by -Tocophenryl Succinate in primary rat hepatocytes in the presence of Phenobarbital. Nutrition and Cancer. 41, 188-195.

29).Yang,Jaw-Ji,(2001), Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Biochem. Biophys.Res. Commun.. 274, 811-816.

30).Tai, K. W., Chou, M. Y., Hu, C. H., Yang, J. J., and Chang, Y. C. ,(2000), Induction of apoptosis in KB cells by pingyangmycin. Oral Oncology. 36, 242-247.